Relationship of polymorphisms in microRNAs -124 e -126 with diabetic retinopathy in patients with type 2 diabetes
نویسندگان
چکیده
Background MicroRNAs (miRs) are small non-coding molecules that regulate gene expression post-transcriptionally by promoting translational repression or degradation of target mRNAs. Altered expression as well as mutations in the sequences of miRs or their target sites have been related to a great number of diseases, including diabetes and its complications. The G allele of the rs531564 (C>G) polymorphism in miR-124 gene was already associated with increased risk of type 2 diabetes mellitus (T2D) and the A allele of the rs4636297 (G>A) polymorphism of miR-126 gene was associated with severity of diabetic retinopathy (DR).
منابع مشابه
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